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Cognition and Psychotherapy in PTSD

NCT03641924 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2025-05-09

Study results available
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Summary

Posttraumatic stress disorder (PTSD) is prevalent among combat Veterans and is a substantial public health burden. Several psychotherapies, including cognitive processing therapy (CPT) and prolonged exposure therapy, have been recommended as efficacious for the treatment of PTSD and are being disseminated nationally in the VA Healthcare System. Yet many individuals show limited benefit from such treatments. Accumulating evidence indicates that episodic memory deficits may be one factor limiting psychotherapy treatment efficacy in PTSD. The proposed study will determine whether verbal memory is a specific predictor of CPT outcomes in PTSD, including both symptom reductions and functional outcomes. The study will also determine the pathways by which memory functioning affects treatment outcomes by examining relationships between memory functioning, treatment engagement, recall of treatment content, and illness course. More specifically, analyses will examine whether memory for treatment content affects the relationship between memory functioning and treatment outcomes.

Conditions

  • Posttraumatic Stress Disorder (PTSD)

Interventions

BEHAVIORAL

Cognitive Processing Therapy

Cognitive Processing Therapy is an evidence-based psychotherapy for PTSD.

Sponsors & Collaborators

  • VA Office of Research and Development

    lead FED

Principal Investigators

  • James C. Scott, PhD · Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-05-20
Primary Completion
2023-09-29
Completion
2023-09-29

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03641924 on ClinicalTrials.gov