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Mechanisms of Type 1 Diabetes Endophenotypes

NCT05764850 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2023-03-13

No results posted yet for this study

Summary

The goal of this observational study consists of performing cluster analysis to decipher underlying disease mechanisms of type 1 diabetes in children and young adults.

To this end, we will combine clinical, laboratory, genetic, transcriptomic, and metabolomic datasets of an extensively phenotyped cohort of children and young adults with type 1 diabetes. We will also assess the risk for cardiovascular diseases in this most vulnerable diabetes cohort.

Conditions

  • Type 1 Diabetes Mellitus
  • Genetic Predisposition to Disease

Interventions

GENETIC

Genome sequencing

100 extensively phenotyped pediatric and young adult patients for genotyping, metabolomic and lipidomic analyses. Polygenic risk scores for type 1 diabetes and cardiovascular disease will be performed. For patients older than 6 years who agree to do a second visit (optional), a Mixed Meal Tolerance Test (MMTT: the gold standard for assessing beta cell function) will be done as well as transcriptomic analysis.

Sponsors & Collaborators

  • University Hospital, Geneva

    collaborator OTHER

  • University of Geneva, Switzerland

    collaborator OTHER

  • Pediatric Clinical Research Platform

    lead OTHER

Principal Investigators

  • Valerie VS Schwitzgebel, MD · University Hospital of Geneva / University of Geneva

Eligibility

Min Age
0 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2026-02-01
Completion
2026-02-01

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05764850 on ClinicalTrials.gov