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Effect of Onchocerciasis Elimination Measures on the Incidence of Epilepsy in Maridi, South Sudan

NCT05750043 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 17000

Last updated 2023-11-30

No results posted yet for this study

Summary

For the first time using a prospective design, a study confirms the results of previous retrospective studies, which found that strengthening onchocerciasis elimination efforts decreases the incidence of epilepsy, including nodding syndrome. Therefore, this study confirms the solid epidemiological link between onchocerciasis and epilepsy.

This study also shows that a community-based "Slash and Clear" vector control method can effectively decrease blackfly biting rates and potentially decrease onchocerciasis transmission.

Moreover, this study shows that epilepsy is a major cause of death in onchocerciasis endemic areas with high ongoing transmission.

Conditions

Interventions

DRUG

bi-annual CDTI

bi-annual community directed treatment with ivermectin (CDTI) and community-based "slash and clear" vector control intervention

Sponsors & Collaborators

  • Amref Health Africa

    collaborator OTHER

  • Universiteit Antwerpen

    lead OTHER

Principal Investigators

  • Jane Carter, MD · Amref Health Africa

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-01
Primary Completion
2023-01-31
Completion
2023-02-19
FDA Drug
Yes

Countries

  • South Sudan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05750043 on ClinicalTrials.gov