Health Benefits of Repeated Treatment in Pediatric Schistosomiasis
NCT01424410 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 360
Last updated 2017-06-14
Summary
Objective and Hypotheses: This project has the overall objective of implementing and evaluating new approaches to reducing the current and future burden of urinary schistosomiasis in young children using the antihelminthic drug praziquantel. The investigators hypotheses are that (1) praziquantel treatment will be as effective in children 1 to 5 years of age (who are routinely excluded from schistosomiasis control programmes) as it is in older 6-10 year old children and (2) two treatments will be more effective than a single treatment, especially in children 1 to 5 years of age.
Conditions
- Schistosomiasis
Sponsors & Collaborators
-
National Institute for Health Research, United Kingdom
collaborator OTHER_GOV -
University of Zimbabwe
collaborator OTHER -
University of Edinburgh
lead OTHER
Principal Investigators
-
Francisca Mutapi, PhD · University of Edinburgh
Eligibility
- Min Age
- 1 Year
- Max Age
- 10 Years
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2012-02-29
- Primary Completion
- 2014-07-31
- Completion
- 2014-11-30
Countries
- Zimbabwe
Study Locations
More Related Trials
-
Assessment of Anaemia Attributable to Schistosomiasis in School Children in Kenya: Mechanisms and Effect of Treatment
NCT00414479 ·Status: COMPLETED
-
A Study of Co-infections of HIV-1 and Schistosoma Mansoni and Its Impact on Praziquantel Treatment Outcomes
NCT01541631 ·Status: UNKNOWN ·Phase: NA
-
Evaluation of Praziquantel Dosage for Treatment of Schistosomiasis in Brazil
NCT00403611 ·Status: COMPLETED ·Phase: PHASE4
-
An Open Label Dose Finding Safety and Efficacy in Children and Infants Infected With Schistosomiasis (S.Mansoni)
NCT02806232 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluation of Strategies for Improved Uptake of Preventive Treatment for Intestinal Schistosomiasis
NCT01869465 ·Status: UNKNOWN ·Phase: NA
-
Using Community-Based Volunteers to Reach Non-Enrolled School Aged Children Through Community-Directed Treatment of Schistosomiasis in School-Aged Children in Rural Northern Ghana
NCT00463931 ·Status: COMPLETED
-
Worm Infestation and Child Health in Zimbabwe
NCT01283165 ·Status: COMPLETED
-
Influence of Transmission Season on Outcome of Treatment of Schistosoma Haematobium Infection in Mozambique
NCT00231322 ·Status: COMPLETED ·Phase: NA
-
L-PZQ ODT in Schistosoma Infected Children
NCT03845140 ·Status: COMPLETED ·Phase: PHASE3
-
Prevention of Female Genital Schistosomiasis (FGS) in Rural High-endemic South Africa
NCT01154907 ·Status: UNKNOWN
-
Schistosoma Haematobium Infections and Praziquantel
NCT01558336 ·Status: COMPLETED ·Phase: PHASE3
-
Schistosomiasis in Formal and Non-Formal Schools in Uganda: Implications for Control Programmes
NCT00463593 ·Status: COMPLETED
-
Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology
NCT02878564 ·Status: COMPLETED ·Phase: PHASE4
-
Iron Supplementation in Schistosomiasis and Soil Transmitted Helminths Control Programmes in Zambia
NCT00276224 ·Status: COMPLETED ·Phase: NA
-
Safety and Efficacy of Drug Combinations Against Triple Infections
NCT01050517 ·Status: COMPLETED ·Phase: NA
-
Schistosome and Intestinal Worm Infections and Malaria Morbidity Among School and Pre-school Children in, Tanzania
NCT00347113 ·Status: COMPLETED ·Phase: NA
-
Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic Infection
NCT00001645 ·Status: RECRUITING
-
Adoption of L-PZQ for Schistosomiasis by Endemic Counties - Social Science Research Study
NCT05350462 ·Status: ACTIVE_NOT_RECRUITING
-
The Chinese-made Praziquantel for Treatment of Schistosoma Haematobium
NCT03133832 ·Status: UNKNOWN ·Phase: PHASE3
-
Schistosoma Mansoni in Mwanza Region, Tanzania
NCT02162875 ·Status: COMPLETED ·Phase: NA
-
Monitoring Schistosome Hybrids Under Under Praziquantel Pressure
NCT04635553 ·Status: UNKNOWN
-
Retrospective Study of Clinical Practice and Management of Imported Schistosomiasis in France
NCT04810741 ·Status: COMPLETED
-
Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis
NCT06376396 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Introduction of Arpraziquantel Treatment for Schistosomiasis Control in Preschool-aged Children in Endemic Areas: A Small-scale Public Health Intervention Study
NCT06698510 ·Status: RECRUITING
-
Taenia Solium Elimination Versus Control: What is the Best Way Forward for Sub-Saharan Africa?
NCT02612896 ·Status: COMPLETED ·Phase: NA