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Onchocerciasis-Associated Epilepsy, an Explorative Case-control Study

NCT05868551 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2023-05-22

No results posted yet for this study

Summary

This is an exploratory case control study with the aim to compare the Onchocerca volvulus virome between persons with onchocerciasis-associated epilepsy (OAE) and persons with onchocerciasis but without epilepsy.

The main question we want to address is: Is there a virus contained in the O. volulus worm that may have a pathogenic role in causing OAE.

In Maridi County, South Sudan, 20 persons with OAE with onchocerciasis nodules, and 20 age- and village-matched controls without OAE will be enrolled in a nodulectomy study.The adult O. volvulus worms will be extracted from the nodules and a viral metagenomic study of the worms. The O. volvulus virome of persons with and without OAE will be compared.

Conditions

  • Onchocercal Subcutaneous Nodule
  • Epilepsy
  • Virus

Interventions

PROCEDURE

nodulectomy

incision in an onchocerciasis nodule to extract adult worms

Sponsors & Collaborators

  • Amref Health Africa

    collaborator OTHER

  • Universiteit Antwerpen

    lead OTHER

Principal Investigators

  • Robert Colebunders, MD · Universiteit Antwerpen

Eligibility

Min Age
12 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-01
Primary Completion
2024-07-01
Completion
2024-12-31

Countries

  • South Sudan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05868551 on ClinicalTrials.gov