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An MRI Ancillary Study of a Malaria Fever Investigation

NCT05746819 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 181

Last updated 2024-04-15

No results posted yet for this study

Summary

This study will seek consent from parents of children enrolled in the Malaria FEVER study to obtain neuroimaging and 12-month neuropsychiatric outcomes data and kidney function on their child. The imaging and evaluations for this observational study will occur after the child has recovered from the acute malaria infection and has otherwise completed the RCT intervention and safety evaluations.

Conditions

  • Brain Injuries
  • Malaria
  • MRI Imaging
  • Neurocognitive Deficits
  • Chronic Kidney Diseases
  • Behavior Problem

Interventions

OTHER

Aggressive antipyretics therapy of fever vs usual care in the Malaria RCT study

After clinical trial of the Malaria RCT study, this study will compare children allocated to aggressive antipyretic therapy vs. usual care on the prevalence of structural brain abnormalities after recovery from CNS malaria.

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • University of Rochester

    lead OTHER

Principal Investigators

  • Karl B Seydel, PhD · Michigan State University, USA

Eligibility

Min Age
2 Years
Max Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-02
Primary Completion
2023-08-31
Completion
2024-03-31

Countries

  • Malawi
  • Zambia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05746819 on ClinicalTrials.gov