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Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment in Malian Children

NCT02504918 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2018-06-14

No results posted yet for this study

Summary

Background:

\- The disease malaria can cause very serious health problems. Researchers want to see if malaria affects the way T cells and vaccines work in the body. If it does, they may need to give malaria treatments before vaccines. They want to check the T cells in children who do or do not get antimalarial treatment.

Objectives:

\- To study the effect of blood stage malaria on T cell suppression and vaccine responses. To describe markers of T cell suppression in children who do or do not receive antimalarial treatment.

Eligibility:

\- Children ages 12 59 months living near Ouelessebougou in Mali. They must have no serious illness.

Design:

* Participants will be screened with medical history and physical exam.
* Some participants will get a course of antimalarial tablets. Some will not. This will be decided at random.
* Participants will have monthly visits for up to a year. They will have blood tests at each visit.

Conditions

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Michal Fried, Ph.D. · National Institute of Allergy and Infectious Diseases (NIAID)

Eligibility

Min Age
12 Months
Max Age
59 Months
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-07-21
Primary Completion
2016-12-31
Completion
2018-06-12

Countries

  • Mali

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02504918 on ClinicalTrials.gov