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Effects of Dexmedetomidine/Lidocaine/Intrathecal Morphine on Cancer Metastasis Biomarker After Colorectal Surgery

NCT05742438 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 114

Last updated 2025-04-02

No results posted yet for this study

Summary

This is a prospective randomized controlled trial. Investigators aimed to compare the effect of three different anesthetic adjuvants (continuous infusion of lidocaine or dexmedetomidine, intrathecal morphine injection) on the biomarker for cancer recurrence and metastasis.

Patients undergoing elective colorectal cancer surgery will be randomly allocated to three parallel arms and the biomarkers for cancer recurrence and metastasis, inflammation, and immune response will be compared. And we will compare the clinical outcomes in the three method.

Conditions

Interventions

DRUG

Lidocaine IV

Continuous intravenous infusion of lidocaine

DRUG

Dexmedetomidine IV

Continuous intravenous infusion of dexmedetomidine

DRUG

intrathecal morphine

intrathecal morphine injection

Sponsors & Collaborators

  • Korea Institute of Science and Technology

    collaborator OTHER

  • Samsung Medical Center

    lead OTHER

Principal Investigators

  • Mihye Park, MD, PhD · Samsung Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-12
Primary Completion
2023-07-05
Completion
2023-08-05

Countries

  • South Korea

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05742438 on ClinicalTrials.gov