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The Danish TURNER Cryopreservation Study

NCT05740579 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2024-05-24

No results posted yet for this study

Summary

The goal of this clinical trial is to investigate if cryopreservation of ovarian tissue in girls with Turner syndrome can improve their fertility and lead to increased number of liveborn babies of Turner syndrome mothers. Women with Turner syndrome suffer from premature ovarian insufficiency which leads to infertility and lack of estrogen.

The main questions it aims to answer are:

* Does the number of pregnancies and liveborn children increase after cryopreservation of ovarian tissue in turner syndrome?
* Is the possible to predict when a girl with Turner syndrome reach menopause using monitoring of sex hormones?
* Is it possible to identify any genes causing ovarian failure in Turner syndrome females?

Participants between 2-18 years old will be asked to participate in a laparoscopic surgery and removal of one ovary in order to cryopreserve the tissue until adulthood. The the cortical tissue will be autotransplanted in order to preserve fertility. The participant will during the study period be monitored using sex hormones.

Furthermore, the investigators wish to investigate the ovarian tissue using RNA sequencing and DNA methylation analysis.

No comparison group is present.

Conditions

  • Fertility Disorders
  • Turner Syndrome
  • Premature Ovarian Failure

Interventions

PROCEDURE

laparoscopic cryopreservation of one ovary

Laparoscopic removal of one ovary as child. In adulthood cortical tissue is replaced in the abdomen in order to improve fertility and pregnancy rates in Turner syndrome women.

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
2 Years
Max Age
17 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2051-01-01
Completion
2051-01-01

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05740579 on ClinicalTrials.gov