Description and Comparison of Biological Vulnerability in Small Vulnerable Newborns Versus Healthy Community Controls in Urban Burkina Faso

Summary

The aim of the DenBalo study is to apply integrated multi-omics methods to examine the biological mechanisms underlying this vulnerability in Small Vulnerable Newborns (SVNs) in LMICs, with the ultimate goal of identifying targeted interventions to reduce morbidity and mortality in this high-risk population. The evidence generated from this project will ultimately help promote healthy pregnancies and the birth of healthy babies.

To achieve this goal, three research objectives are proposed:

1. To describe and compare gut microbiota, immune system and breastmilk components in SVNs versus healthy community controls in urban Burkina Faso.
2. To describe and compare the development of the gut microbiota, the immune system and breastmilk components during the first six months of life in SVNs versus healthy community controls in urban Burkina Faso.
3. To investigate the relationship between the composition of the gut microbiota, the immune system and breastmilk components during the first six months of life in SVNs versus healthy community controls in urban Burkina Faso.

Conditions

• Preterm Birth
• Low Birth Weight
• Small for Gestational Age at Delivery

Sponsors & Collaborators

• Institut de Recherche en Sciences de la Santé (IRSS)

  collaborator UNKNOWN

• Université NAZI BONI

  collaborator OTHER

• Hasselt University

  collaborator OTHER

• University of Virginia

  collaborator OTHER

• University Hospital, Ghent

  collaborator OTHER

• Cedars-Sinai Medical Center

  collaborator OTHER

• Sapient Bioanalytics

  collaborator UNKNOWN

• Stanford University

  collaborator OTHER

• Centre Muraz

  collaborator OTHER

• University of Manitoba

  collaborator OTHER

• Manitoba Interdisciplinary Lactation Center (MILC)

  collaborator UNKNOWN

• Agence de Formation, de Recherche & d'Expertise en Santé pour l'Afrique (AFRICSanté)

  collaborator UNKNOWN

• University Ghent

  lead OTHER

Principal Investigators

• Trenton Dailey-Chwalibóg, MPH, PhD · University Ghent

• Carl Lachat, MEng, PhD · University Ghent

Eligibility

Min Age

15 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-01-09

Primary Completion

2024-07-31

Completion

2024-07-31

Countries

• Burkina Faso

Study Locations