Smart Discharges to Improve Post-discharge Health Outcomes in Children

Summary

In Uganda, about 5% of children discharged after hospitalization for a serious infection will die in the weeks after returning home. Doctors and parents are often unaware of this period of vulnerability and are poorly equipped to identify or handle this critical situation. This project builds on past work to develop and evaluate models and technology to predict, before discharge, an individual child's risk of recurrent illness, as well as to provide additional post-discharge support to at-risk children. This study seeks to evaluate the effect of a novel "Smart Discharges" approach on childhood mortality and health seeking behaviour.

Conditions

• Sepsis

Interventions

BEHAVIORAL

Risk-stratified discharge and post-discharge care

Interventional intensity is based on predicted risk. Predicted risk based on previously developed prediction algorithms. Low risk: receive discharge education and counselling only; Moderate risk: Discharge education and counselling + 1 post-discharge follow-up referral at day 7; High risk: Discharge education and counselling + 3 post-discharge follow-up referrals (D2, D7, D14); Very high risk: Discharge education and counselling + 3 post-discharge follow-up referrals (D2, D7, D14, D28)

Sponsors & Collaborators

• Walimu

  collaborator OTHER

• Mbarara University of Science and Technology

  collaborator OTHER

• Grand Challenges Canada

  collaborator OTHER

• Thrasher Research Fund

  collaborator OTHER

• British Columbia Childrens Hospital Foundation

  collaborator OTHER

• University of British Columbia

  lead OTHER

Principal Investigators

• Matthew O Wiens, PharmD, PhD · University of British Columbia

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

SEQUENTIAL

Eligibility

Min Age

0 Days

Max Age

59 Months

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-07-16

Primary Completion

2024-01-31

Completion

2024-03-31

Countries

• Canada

Study Locations