Prediction of Disease Severity in Young Children Presenting With Acute Febrile Illness in Resource-limited Settings

Summary

Note that this is a study that is co-sponsored by Medecins Sans Frontieres, Spain, and the University of Oxford.

The primary objective is to develop a risk prediction algorithm, combining measurements of host biomarkers and clinical features at the point-of-triage, for children with an acute febrile illness in resource-limited settings.

The secondary objectives are to determine which host biomarkers, feasible for measurement at the point-of-care, are predictive of disease severity. Additionally to determine the optimal combination of clinical features (including demographics, anthropometric data, historical variables, vital signs, clinical signs and clinical symptoms), feasible for assessment by limited-skill health workers, that is predictive of disease severity.

The tertiary objectives are to explore the impact of different methods of outcome classification on development of the risk prediction algorithm, and to explore the performance of the algorithm to predict disease severity in key presenting clinical syndromes and aetiologies.

Conditions

• Sepsis

Sponsors & Collaborators

• Mahidol Oxford Tropical Medicine Research Unit

  collaborator OTHER

• Gadjah Mada University

  collaborator OTHER

• Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit

  collaborator OTHER

• Cambodia Oxford Medical Research Unit

  collaborator UNKNOWN

• University of Medicine and Pharmacy at Ho Chi Minh City

  collaborator OTHER

• Research Institute for Tropical Medicine, Philippines

  collaborator OTHER_GOV

• International Centre for Diarrhoeal Disease Research, Bangladesh

  collaborator OTHER

• Hanoi Medical University

  collaborator OTHER

• Medecins Sans Frontieres, Spain

  lead OTHER

Principal Investigators

• Sakib Burza, PhD · Medecins Sans Frontieres, Spain

• Yoel Lubell, PhD · Mahidol Oxford Tropical Medicine Research Unit

Eligibility

Min Age

28 Days

Max Age

5 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-03-05

Primary Completion

2022-11-30

Completion

2022-11-30

Countries

• Bangladesh
• Cambodia
• Indonesia
• Laos
• Vietnam

Study Locations