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Genetic Risk Factors for Multi-system Inflammatory Syndrome in Children and Pediatric Post COVID Condition

NCT05722717 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2023-02-10

No results posted yet for this study

Summary

We will perform Whole Exome Sequencing on DNA from saliva. We will include: Children with a history of MIS-C; children with post-COVID condition; and controls in order to identify rare, high impact genetic variants in immunological genes and pathways in children with a history of MIS-C or pediatric post-COVID condition.

Conditions

  • COVID-19
  • Post-Acute COVID-19
  • Post-Acute COVID19 Syndrome
  • Multi-System Inflammatory Syndrome in Children
  • Pediatric Inflammatory Multisystem Syndrome
  • Post COVID-19 Condition
  • Post-COVID-19 Syndrome

Interventions

GENETIC

Saliva collection at home

Children (with help of their parents) collect their saliva with a saliva collection kit which they send to our research center.

Sponsors & Collaborators

  • ZonMw: The Netherlands Organisation for Health Research and Development

    collaborator OTHER

  • University Medical Center Groningen

    collaborator OTHER

  • UMC Utrecht

    collaborator OTHER

  • Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

    collaborator OTHER

  • Leiden University Medical Center

    lead OTHER

Principal Investigators

  • Emmeline P Buddingh, MD, PhD · Leiden University Medical Center

Eligibility

Min Age
0 Months
Max Age
19 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-06-28
Primary Completion
2024-01-31
Completion
2024-01-31

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05722717 on ClinicalTrials.gov