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the Effects of Platelet-Rich Plasma on Postoperative Complications After Meningomyelocele

NCT05711355 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2023-02-03

No results posted yet for this study

Summary

Introduction: Meningomyelocele is a common congenital neural tube defect. To reduce complications, early surgery and a multidisciplinary approach is needed. In this study, the investigators administered platelet-rich plasma (PRP) to newborns with meningomyelocele following corrective surgery to minimize cerebrospinal fluid (CSF) leakage and accelerate the healing of the immature pouch tissue. The investigators compared these with a control group that did not receive PRP.

Patients and Methods: Of the 40 newborns who were operated on with the diagnosis of meningomyelocele, 20 patients received PRP after surgical repair, and 20 were followed up without PRP. In the PRP group, 10 of the 20 patients underwent primary defect repair, the other 10 underwent flap repair. In the group that did not receive PRP, primary closure was performed in 14 patients and flap closure in six.

Conditions

  • Meningomyelocele/Spina Bifida

Interventions

PROCEDURE

Use of Platelet-Rich Plasma after meningomyelocele sac repair

Wound healing with the use of Platelet-Rich Plasma after surgical meningomyelocele pouch repair

PROCEDURE

meningomyelocele sac repair

meningomyelocele sac repair without Platelet-Rich Plasma

Sponsors & Collaborators

  • Yuzuncu Yıl University

    lead OTHER

Principal Investigators

  • Mehmet Edip Akyol, Ass. Prof · Van Yuzuncu Yıl Unıversty

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
1 Day
Max Age
1 Month
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-15
Primary Completion
2022-11-15
Completion
2022-12-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05711355 on ClinicalTrials.gov