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Expression of microRNA-133a and microRNA-208b in Acute Myocardial Infarction

NCT05692752 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2023-01-20

No results posted yet for this study

Summary

Cardiac-enriched micro-RNAs (miRNAs), micro RNA 208b and 133a(MiR-208b, MiR-133a)) corresponds to the health and disorders of the cardiovascular system. An intron of the cardiac myosin heavy chain gene MYH7 encodes miR-208b. It is found on chromosome 14 in humans. Identify new diagnostic biomarkers based on miRNAs, researchers examine the expression of miR-133a and 208b at various time points (04 hours, 08 hours, 12 hours, 24 hours, 48 hours) following the development of the infarct and compared it to the traditional myocardial infarction biomarkers cardiac troponine (cTnl) and Creatine kinase-MB (CK-MB).

Conditions

  • Myocardial Infarction, Acute

Interventions

OTHER

No intervention

Expression of miR-133a \&208b at 4, 8, 12, 24 and 48 hours from the first appearance of myocardial infarction (MI) symptoms

Sponsors & Collaborators

  • German University in Cairo

    collaborator OTHER

  • Islamia University of Bahawalpur

    lead OTHER

Principal Investigators

  • Sally I Hassanien, Ph.D · Biochemistry Department German University in Cairo, 11835, Cairo, Egypt

  • Hafiz A Sattar, M.Phil · University College of Conventional Medicine, The Islamia University of Bahawalpur, Punjab, Pakistan

Eligibility

Min Age
35 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-12-28
Primary Completion
2023-01-10
Completion
2023-01-14

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05692752 on ClinicalTrials.gov