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Mi-RNAs and Specificity of Hs-TnT in Symptomatic ED Patients

NCT02116153 · Status: UNKNOWN · Type: OBSERVATIONAL

Last updated 2014-04-16

No results posted yet for this study

Summary

Biomarkers play a key role in the diagnostic workup of patients presenting to an emergency department (ED). European and American guidelines recommend cardiac Troponin (T or I) as the biomarker gold standard for the diagnosis of non-ST-elevation myocardial infarction (non-STEMI). Today, high-sensitivitiy assays are available and allow an early diagnosis of non-STEMI and the detection of troponin in individuals that would have been classified as unstable angina with former assays. As many patients are detected with elevated troponin values with the high sensitivity assays, specificity for non-STEMI has inevitably decreased. Micro-RNAs (mi-RNA) are new biomarkers with a wide spectrum of detectable conditions that allow specific identification of myocardial infarction. The aim of this study is to develop a biomarker protocol that combines the high sensitivity of cardiac Troponin T and the high specificity of mi-RNA profiles for early and safe identification of non-STEMI in ED patients.

Conditions

Sponsors & Collaborators

  • Deutsche Stiftung für Herzforschung

    collaborator OTHER

  • University Hospital Heidelberg

    lead OTHER

Principal Investigators

  • Evangelos Giannitsis, MD · University Hospital Heidelberg

  • Hugo A Katus, MD · University Hospital Heidelberg

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-06-30
Primary Completion
2015-12-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02116153 on ClinicalTrials.gov