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A Longitudinal, Observational Study of Primary Ciliary Dyskinesia in Adults

NCT05685186 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 31

Last updated 2026-05-04

No results posted yet for this study

Summary

The goal of this observational study is to characterize clinical measures and biomarkers of airway disease in adults with primary ciliary dyskinesia (PCD) and in a group of healthy volunteers (HV) to establish normative values. Lung function, mucociliary clearance, radiological findings, and clinical findings will be assessed. Furthermore, quality of life will be assessed using QOL-PCD, a disease specific questionnaire.

Conditions

  • Primary Ciliary Dyskinesia

Interventions

DIAGNOSTIC_TEST

Spirometry

To assess lung function

DIAGNOSTIC_TEST

Multiple Breath Washout (MBW)

To measure Lung Clearance Index (LCI)

DIAGNOSTIC_TEST

Mucociliary Clearance (MCC)

To measure lung clearance after the inhalation of radiolabeled particles

DIAGNOSTIC_TEST

CT of the chest

Low radiation to assess structural lung disease

DIAGNOSTIC_TEST

MRI of the chest

To assess lung function and structural lung disease

Sponsors & Collaborators

  • University of North Carolina, Chapel Hill

    collaborator OTHER

  • ReCode Therapeutics

    lead INDUSTRY

Principal Investigators

  • Priya Ryali · ReCode Therapeutics

  • Stephanie Davis · UNC Chapel Hill

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-03-08
Primary Completion
2025-04-28
Completion
2025-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05685186 on ClinicalTrials.gov