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The Natural History of Small Airways Physiology in Diseased and Healthy States

NCT00677560 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 126

Last updated 2021-12-20

Study results available
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Summary

Spirometry is a useful clinical tool for the assessment and monitoring of lung disease, however, it does not provide information on peripheral airways resistance. On the contrary, impulse oscillometry (IOS) may provide information not only on airway resistance (Rrs) but also on the elastic properties of the lung (Xrs). In addition, multiple breath nitrogen washout (MBNW) utilizes the exhalation of nitrogen gas from the airways to determine changes in lung ventilation and derive small airways indices (that tells us about small airways calibre). This method, like IOS, allows a precise assessment of small airways function.

Even though patients with asthma may show some reduction of the caliber of the small airways these changes are more a feature of patients with COPD. The study team hypothesize that IOS and MBNW measurements may detect these differences and provide different resistance profiles for asthma and COPD. Furthermore, the study team would like to investigate the relationship between airway inflammation and small airway disease by measuring exhaled nitric oxide (NO) at multiple exhalation flow rates. This technique allows the partitioning of NO produced in the central airways from that generated more peripherally in the lung, providing valuable information on the activity of inflammation in different parts of the respiratory system. The study team hope that the combined use of IOS, MBNW and NO will identify a possible correlation between inflammation and small airway dysfunction.

Conditions

Sponsors & Collaborators

  • Imperial College London

    lead OTHER

Principal Investigators

  • Paolo Paredi, MD, PhD · Airway Disease Section, National Heart and Lung Institute, Imperial College, London

  • Omar A Usmani, MD, PhD · Airway Disease Section, National Heart and Lung Institute, Imperial College, London

  • Peter J Barnes, Prof · Airway Disease Section, National Heart and Lung Institute, Imperial College, London

  • Neil Pride, Prof · Airway Disease Section, National Heart and Lung Institute, Imperial College, London

  • Michael Goldman, Prof · Airway Disease Section, National Heart and Lung Institute, Imperial College, London

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-06-22
Primary Completion
2013-07-10
Completion
2013-07-10

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00677560 on ClinicalTrials.gov