Characterizing the Inflammation Around Dental Implants

Summary

The use of titanium dental implants has become a common modern treatment to restore teeth. Although the success rate of dental implants is high, inflammation around the dental implant still occurs. The current study will investigate if the inflammation around the implant is due to bacterial infection, hypersensitivity or both.

The goal of this cross-sectional study is to (1) Establish the levels of cytokines in peri-implant crevicular fluid associated with bacterial infection and hypersensitivity reaction; (2) Compare the levels of cytokines associated with hypersensitivity and bacterial infection between healthy implants and inflamed implants (peri-mucositis and peri-implantitis); (3) Determine whether the difference in the levels of cytokines, if they exist, reflects the clinical diagnosis of healthy implants and inflamed implants.

Conditions

• Peri-Implantitis
• Peri-implant Mucositis
• Implant Site Reaction
• Implant Site Infection
• Hypersensitivity
• Implant Site Rash
• Implant Infection

Interventions

DIAGNOSTIC_TEST

Clinical examination of a dental implant

Clinical examination includes bleeding on probing, pocket depth, gingival biotype, suppuration, gingival index

DIAGNOSTIC_TEST

Radiological Examination

A standardized periapical radiograph in parallax technique will be taken.

DIAGNOSTIC_TEST

Peri-implant crevicular fluid sample collection

A sample of the peri-implant crevicular fluid will be collected using paper strip for 60 seconds. The sample of the fluid will be a resultant of inserting six different strips at the same time in six sites of the implant including mesiobuccal, midbuccal, distobuccal, distopalatal/distolingual, midpalatal/midlingual, mesiopalatal/mesiolingual sites of the implant.

Sponsors & Collaborators

• McGill University Health Centre/Research Institute of the McGill University Health Centre

  collaborator OTHER

• McGill University

  lead OTHER

Principal Investigators

• Heba Allah Madi Dr · McGill University

• Jocelyne Feine Dr · McGill University

• Nicholas Makhoul Dr · McGill University & McGill University Health Centre

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2022-09-01

Primary Completion

2023-12-01

Completion

2024-12-01

Countries

• Canada

Study Locations