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Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis

NCT05834946 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 29

Last updated 2023-10-18

No results posted yet for this study

Summary

This prospective parallel, double-blind, four-arm randomised controlled clinical study is planned to assess the difference in the level of the inflammatory biomarkers expressed following the placement of the first dental implant in patients with history of periodontitis (successfully treated) and healthy controls without the disease, during implant osseointegration period. The subjects in both groups will also be randomised to receive one of the two types of implants provided which have different surface treatment.

Conditions

  • Periodontitis
  • Peri-implant Mucositis
  • Peri-Implantitis

Interventions

OTHER

Megagen implant placement

Megagen implant with sand-blasted, large-grit, acid-etched (SLA) and nano-calcium ions incorporated surface

OTHER

Biomate-Swiss implant

Biomate-Swiss implant with precision dimension laser (PDL) surface

Sponsors & Collaborators

  • University of Malaya

    lead OTHER

Principal Investigators

  • Norul H Mohamad-Hassan, DDS,MCD · University of Malaya

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-04
Primary Completion
2023-05-30
Completion
2025-05-30

Countries

  • Malaysia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05834946 on ClinicalTrials.gov