Clinical and Biochemical Evaluation of the Efficacy of Non-Surgical Treatment Approaches in the Treatment of Peri-implantitis

Summary

Peri-implantitis is a pathological condition associated with plaque that develops around dental implants, characterized by inflammation and progressive bone loss in the peri-implant area. Bleeding on probing, suppuration, increased pathological pocket depths and/or mucosal recessions are seen with radiographic bone loss in peri-implantitis. When evaluated histologically, the lesion extends to the apical part of the pocket epithelium and contains a large amount of plasma cells, macrophages and neutrophils. In the Peri-implant crevicular fluid analysis, which is one of the most important parameters that enable the biochemical and immunological evaluation of the inflammatory state in the peri-implant region, information about the current inflammatory situation can be obtained by evaluating the content of an osmotic inflammatory exudate originating from the vessels in the gingival plexus. Many surgical and non-surgical methods have been proposed for the treatment of peri-implantitis. Mechanical surface debridement, laser application and air abrasives are a part of non-surgical treatment of peri-implantitis. In this study, we examined the effectiveness of diode laser in addition to mechanical debridement with titanium curettes. In our study, we aimed to compare these two treatments biochemically by determining the changes in interleukin-1β, Interleukin-10, Interleukin-17, RANKL, osteoprotegerin, TWEAK and sclerostin biomarkers in Peri-implant crevicular fluid and clinically.

Conditions

• Peri-Implantitis

Interventions

DEVICE

Diode laser

Diode Laser is applied to one group as an adjunctive therapy.

DEVICE

Titanium curettes

Non-surgical treatment with titanium curettes were administrated to both groups.

Sponsors & Collaborators

• Hacettepe University

  lead OTHER

Principal Investigators

• Güliz Nigar GÜNCÜ, Prof. Dr. · study director

• Abdullah Cevdet AKMAN, Prof Dr · Principal Investigator

• Rahime Meral NOHUTCU · Principal Investigator

• Ali Tuğrul GÜR, Phd · Principal Investigator

• Aslı PINAR, Prof Dr · biochemistry

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2018-11-12

Primary Completion

2022-04-30

Completion

2022-10-31

Countries

• Turkey (Türkiye)

Study Locations