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Diaphragmatic Ultrasound and Weaning After Lung Transplant.

NCT05670327 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 43

Last updated 2023-01-04

No results posted yet for this study

Summary

The prevalence and adverse effect of diaphragm dysfunction (DD) after bilateral-lung transplant (LT) are still unclear, despite a well-known negative impact on weaning and outcome in other cohorts of critically ill and surgical patients.

Objects: The primary aim is investigating the prevalence of DD, assessed using point-of-care ultrasound and defined as diaphragm thickening fraction (TFdi) \< 29%, at the first weaning trial after LT.

Secondary aims are investigating the impact of DD on weaning (defined success or failure according to pre-defined criteria, neuroventilatory efficiency (EAdi or NVE), perioperative (14-day) pneumonia, ICU length of stay (LOS), in-hospital mortality, and identifying potential risk factors for DD. Moreover, we aim to study the correlation between TFdi versus EAdi/NVE and the rapid shallow breathing index (RSBI), respectively.

Conditions

  • Diaphragm
  • Diaphragm Disease
  • Diaphragm Issues
  • Weakness, Muscle

Interventions

OTHER

Diaphragmatic ultrasound assessment

TFdi, diaphragmatic dysplacement, NAVA assessment, respiratory paramenters

Sponsors & Collaborators

  • University of Padova

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-06-22
Primary Completion
2022-10-19
Completion
2022-12-01

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05670327 on ClinicalTrials.gov