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Lung Ultrasound, PEEP and Overdistension (LUPO)

NCT04648657 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2022-04-26

No results posted yet for this study

Summary

The investigators suppose that lung sliding could be reduced in the same lung region moving from less ventilated to overinflated condition. This is supported by theoretical arguments by some authors but so far it has not been demonstrated.

The investigators suppose that speckle tracking applied to LUS is able to demonstrate a reduction or abolition in pleural sliding when lung tissue is overinflated by higher PEEP after lung recruitment maneuver. The overinflation is diagnosed by Electric Impedance Tomography (EIT) and mechanical respiratory measurements (reduction in compliance as ratio between tidal volume over difference between plateau pressure and PEEP) and localized by EIT.

Conditions

  • Hypoxic Respiratory Failure

Interventions

DEVICE

Lung Ultrasound

Echography of Lungs based on artifacts study

DEVICE

Electric impedance tomography

Low alternating electrical currents (usually \<5 milliampere at 50-80 kHz) applied through different pair of electrodes on thorax

Sponsors & Collaborators

  • University of Padova

    lead OTHER

Principal Investigators

  • Paolo Navalesi, MD · University of Padova

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-25
Primary Completion
2021-04-30
Completion
2021-05-15

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04648657 on ClinicalTrials.gov