A Precision Medicine Approach to Target Engagement for Emotion Regulation

Summary

The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of participants to receive their predicted optimal or non-optimal skills to determine if it is feasible and efficacious to match participants to the most appropriate training condition. Results of these studies may identify the mechanisms by which emotion regulation interventions impact emotional functioning and allow for the development of personalized, evidence-based, and scalable emotion regulation interventions.

Conditions

• Emotional Regulation
• Depression
• Anxiety
• Borderline Personality Disorder
• Obsessive-Compulsive Disorder
• Posttraumatic Stress Disorder
• Eating Disorders

Interventions

BEHAVIORAL

Checking the Facts

Checking the Facts is a form of cognitive reappraisal in which participants identify negatively-valenced automatic thoughts and both generate and consider evidence that challenges the validity of those thoughts.

BEHAVIORAL

Opposite to Emotion Action

Opposite to Emotion Action teaches participants to identify their momentary emotion(s), identify the associated behavioral urge(s), and implement a behavior inconsistent with that urge (e.g., approaching a feared stimulus instead of avoiding it).

BEHAVIORAL

Mindfulness of Current Emotions

Mindfulness of Current Emotions teaches participants to nonjudgmentally observe the experience of their emotions, including physiological and cognitive responses to those emotions.

Sponsors & Collaborators

• National Institute of Mental Health (NIMH)

  collaborator NIH

• Matthew Southward, PhD

  lead OTHER

Principal Investigators

• Matthew W Southward, Ph.D. · Ohio State University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-09-29

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• United States

Study Locations