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Mechanisms of Emotion Regulation Underlying Successful CBT in Depression

NCT04328103 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 41

Last updated 2024-05-16

No results posted yet for this study

Summary

This research aims to elucidate mechanisms through which change occurs during cognitive behavior therapy (CBT) for depression. Assessing meta-cognitive processes of self-knowledge (top-down), electrophysiological and behavioral correlates of emotion processing (bottom-up), and their relation to treatment outcome will provide new insights into the mechanisms of emotion regulation deficits in depression. It will also contribute toward the clinical goal of identifying patients who may benefit most from CBT for unipolar depression.

Conditions

Interventions

BEHAVIORAL

Cognitive Behavior Therapy (CBT)

Following established procedures at the DES at NYSPI, 12 sessions of individual manual-driven CBT (Emery, 2000) will be conducted by highly trained master degree clinicians.

BEHAVIORAL

Nonspecific Supportive Therapy (PBO)

As a non-CBT intervention that includes warmth, genuineness and empathy (Linde et al., 2011), nonspecific supportive therapy (PBO) will be administered in a parallel format to CBT, also consisting of 12 individual sessions.

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • New York State Psychiatric Institute

    lead OTHER

Principal Investigators

  • Jürgen Kayser, PhD · NYSPI/RFM/CU

  • Ronit Kishon, PhD · NYSPI/RFM/CU

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-25
Primary Completion
2023-06-02
Completion
2023-06-02

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04328103 on ClinicalTrials.gov