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The Relationship Between Inflammatory ARTritis and CArdiac DIseAse

NCT05647577 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 1285

Last updated 2024-02-28

No results posted yet for this study

Summary

The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to collectively as inflammatory arthritis (IA). The main questions it aims to answer are:

* Using conventional echocardiography, the investigators aim to determine the prevalence of overt and asymptomatic cardiac dysfunction in a large random sample of outpatients with IA. Cardiac dysfunction will be evaluated by echocardiography and cardiac biomarkers (NT-pro-BNP, hs-TNT and hs-CRP).
* In patients without known heart disease: Using 2, 5 and 10 year follow-up, the investigators aim to examine if advanced echocardiography can be used to detect early signs of heart disease by investigating the clinical significance of adding deformation measures - alone and in combination with selected biomarkers - to conventional risk factors in the cardiac risk assessment of patients with IA

Participants will undergo an echocardiographic examination in combination with a general health assessment including obtainment of cardiac biomarkers and a electrocardiogram.

Using advanced echocardiography - Tissue Doppler Imaging, 2- dimensional speckle tracking echocardiography, 3D-echocardiography and 3-dimensional speckle tracking echocardiography - the investigators also aim to compare myocardial deformation parameters of patients with IA to a gender and age matched control group without IA from the Copenhagen City Heart Study.

Conditions

  • Inflammatory Arthritis
  • Rheumatoid Arthritis
  • Spondylitis, Ankylosing
  • Axial Spondyloarthritis
  • Spondyloarthritis
  • Heart Failure
  • Ischemic Heart Disease
  • Valvular Heart Disease
  • Left Ventricular Systolic Dysfunction
  • Heart Failure, Systolic
  • Heart Failure, Diastolic
  • Myocardial Infarction
  • Myocardial Dysfunction
  • Cardiac Disease
  • Stroke

Sponsors & Collaborators

  • University Hospital, Gentofte, Copenhagen

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2025-03-01
Completion
2033-03-01

Countries

  • Denmark

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05647577 on ClinicalTrials.gov