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MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE

NCT05645861 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 550

Last updated 2026-01-05

No results posted yet for this study

Summary

Stroke is the third most common cause of death in New Zealand and is one of the leading causes of long-term disability at all ages. A life-saving clot retrieval procedure can save lives and prevent disability of patients with ischaemic stroke who get to hospital in time. In New Zealand, 90% of clot retrieval procedures are performed under general anaesthesia. Many anaesthetic drugs can affect blood pressure (BP) and blood flow within the brain. Increasing BP during the procedure could provide additional benefits in this devastating disease. A large trial is needed to investigate BP management during clot retrieval.

Conditions

  • Stroke
  • Embolus Cerebral
  • Blood Pressure

Interventions

PROCEDURE

Blood pressure management of Systolic Blood Pressure to maintain target range +/- 10 mmHg

Techniques used to target SBP will not be controlled for and will be at the discretion of the procedural anaesthetist to manage blood pressure, this can include vasopressors, intravenous fluids, titration of anaesthetic maintenance drugs and use of other vasoactive drugs.

Sponsors & Collaborators

  • The Australian and New Zealand College of Anaesthetists (ANZCA)

    collaborator UNKNOWN

  • Neurological Foundation of New Zealand

    collaborator UNKNOWN

  • The University of Queensland

    collaborator OTHER

  • Auckland Medical Research Foundation

    collaborator OTHER

  • Auckland Hospitals Research and Endowment Fund

    collaborator UNKNOWN

  • Auckland City Hospital

    lead OTHER_GOV

Principal Investigators

  • Doug Campbell, Dr · Auckland City Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-11-28
Primary Completion
2026-01-31
Completion
2026-02-28

Countries

  • Australia
  • New Zealand

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05645861 on ClinicalTrials.gov