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Impact of Dietary Fiber Supplementation on Colonic Microbiome

NCT05643859 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2026-01-15

No results posted yet for this study

Summary

This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health. Certain microbial strains are associated with the growth of colon polyps, which eventually could go on to form colon cancer. Giving dietary fiber supplements may help prevent precancerous polyps from ever developing.

Conditions

  • Benign Colorectal Neoplasm
  • Non-Neoplastic Anal Disorder

Interventions

DIETARY_SUPPLEMENT

Dietary Fiber

Given PO

PROCEDURE

Proctoscopy or anoscopy with Biopsy

Undergo proctoscopy or anoscopy

PROCEDURE

Colonoscopy

Undergo Colonoscopy

OTHER

Questionnaire Administration

Ancillary studies

Sponsors & Collaborators

  • OHSU Knight Cancer Institute

    lead OTHER

Principal Investigators

  • Vassiliki L Tsikitis, M.D. · OHSU Knight Cancer Institute

Study Design

Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-01
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05643859 on ClinicalTrials.gov