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Comparing Intubation Rates in the Delivery Room by Interface

NCT05609773 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 42

Last updated 2022-12-20

No results posted yet for this study

Summary

Although the majority of premature neonates \< 30 weeks gestion require positive pressure ventilation (PPV) at birth, the optimal interface to provide PPV has not been determined. Preferably this support would be provided by non-invasive means to prevent the development of bronchopulmonary dysplasia. Resuscitation with a face mask, single nasal tube, nasal prongs, and/or LMA are all approved methods of resuscitation per NRP as of 2010. Face masks have been associated with more dead space, air leak and airway obstruction however are the most commonly used interface. Recently, the Trigeminal Cardiac Reflex has been described, which can be induced with the placement of a facemask, resulting in bradycardia and apnea. Bi-nasal prongs (RAM cannula) have been found in studies to be associated with lower intubation rates in the delivery room (down to 24 weeks gestation), less need for epinephrine, chest compressions, and subsequent invasive ventilation. In addition to the potential practical advantages of bi-nasal prong resuscitation, there is evidence to suggest that ventilation through the nose may stimulate the subepithelial receptors of the upper airways causing an increase in respiratory rate and depth.

Conditions

  • Ventilator Lung; Newborn

Sponsors & Collaborators

  • Children's Hospital of Illinois

    collaborator UNKNOWN

  • OSF Healthcare System

    collaborator OTHER

  • University of Illinois College of Medicine at Peoria

    lead OTHER

Principal Investigators

  • Ashley Fischer, MD · University of Illinois College of Medicine at Peoria

Eligibility

Min Age
0 Weeks
Max Age
30 Weeks
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-22
Primary Completion
2025-09-22
Completion
2025-09-22

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05609773 on ClinicalTrials.gov