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Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation

NCT07237139 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 27

Last updated 2025-12-09

No results posted yet for this study

Summary

Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress syndrome (RDS), both as initial and post-extubation support. NIPPV may be delivered in synchronized (sNIPPV) or non-synchronized (nsNIPPV) modes, with sNIPPV offering clear benefits by coordinating support with the infant's own breathing. Recent studies indicate sNIPPV is superior to nsNIPPV in preventing respiratory failure, though the intrapulmonary mechanisms behind this advantage remain unclear. To address this, the present study uses Electrical Impedance Tomography (EIT) to evaluate how lung volume changes during different types of breaths and ventilator inflations - spontaneous breaths, synchronized inflations, non-synchronized inflations, and backup inflations - in preterm infants receiving sNIPPV.

Conditions

  • Infant, Preterm
  • Respiratory Distress Syndrome (Neonatal)
  • Chronic Lung Disease of Newborn
  • Respiratory Support
  • Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)
  • Lung Volume

Interventions

DEVICE

Electrical Impedance Tomography (EIT)

Electrical Impedance Tomography and clinical data will be recorded continuously. Corresponding data will be extracted and analyzed at five pre-defined timepoints.

Sponsors & Collaborators

  • University Hospital, Zürich

    collaborator OTHER

  • University of Zurich

    lead OTHER

Principal Investigators

  • Vincenzo Cannizzaro, MD · Newborn Research, Department of Neonatology, University Hospital and University of Zurich, Zurich, Switzerland

Eligibility

Max Age
4 Weeks
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-11-17
Primary Completion
2026-12-31
Completion
2027-01-30

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07237139 on ClinicalTrials.gov