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Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

NCT05603741 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 155

Last updated 2024-12-18

No results posted yet for this study

Summary

Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers. The investigators propose to collect such objective data on the frequency of drug resistance and whether any problems with local anesthesia are due to initial ineffectiveness or due to its effects dissipating too soon.

Conditions

  • Ehlers-Danlos Syndrome
  • Anesthesia, Local

Interventions

DRUG

0.9% Sodium Chloride Injection

All participants will be injected subcutaneously with a single 0.5ml dose

DRUG

Lidocaine Injection 2%

All participants will be injected subcutaneously with a single 0.5ml dose

Sponsors & Collaborators

  • Vanderbilt University Medical Center

    collaborator OTHER

  • University of Calgary

    lead OTHER

Principal Investigators

  • Satish R Raj, MD MSCI · University of Calgary

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-11-10
Primary Completion
2027-01-31
Completion
2027-06-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05603741 on ClinicalTrials.gov