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Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

NCT04036305 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 230

Last updated 2025-10-14

No results posted yet for this study

Summary

Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers. We propose to collect such objective data on the frequency of drug resistance and whether any problems with local anesthesia are due to initial ineffectiveness or due to its effects dissipating too soon.

Conditions

  • Ehlers-Danlos Syndrome
  • Anesthesia, Local

Interventions

DRUG

0.9% Sodium Chloride Injection

All participants will be injected subcutaneously with a single 0.5ml dose

DRUG

Lidocaine Injection 2%

All participants will be injected subcutaneously with a single 0.5ml dose

DRUG

Bupivacaine Injection 0.5%

All participants will be injected subcutaneously with a single 0.5ml dose

Sponsors & Collaborators

  • University of Calgary

    collaborator OTHER

  • Vanderbilt University Medical Center

    lead OTHER

Principal Investigators

  • Satish R Raj, MD MSCI · Vanderbilt University Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-07-26
Primary Completion
2029-12-31
Completion
2029-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04036305 on ClinicalTrials.gov