Fractional Laser Assisted Delivery of Anesthetics IIIb

Summary

The purpose of this study are to compare the efficacy of two different commercially available local anesthetics on AFXL pretreated skin and to assess the role of the application time in this technique.

Conditions

• Local Anesthesia of the Skin

Interventions

DRUG

AHES 5 minutes

Topical application of AHES with 5 minutes application time After 5 minutes: pain stimulus with the fractional CO2 laser, 50 mJ, 5% density

DRUG

AHES 15 minutes

Topical application of AHES with 15 minutes application time After 15 minutes: pain stimulus with the fractional CO2 laser, 50 mJ, 5% density

DRUG

AHES 25 minutes

Topical application of AHES with 25 minutes application time After 25 minutes: pain stimulus with the fractional CO2 laser, 50 mJ, 5% density

DRUG

LTC 5 minutes

Topical application of LTC with 5 minutes application time After 5 minutes: pain stimulus with the fractional CO2 laser, 50 mJ, 5% density

DRUG

LTC 15 minutes

Topical application of LTC with 15 minutes application time After 15 minutes: pain stimulus with the fractional CO2 laser, 50 mJ, 5% density

DRUG

LTC 25 minutes

Topical application of LTC with 25 minutes application time After 25 minutes: pain stimulus with the fractional CO2 laser, 50 mJ, 5% density

DEVICE

fractional CO2 laser, 50 mJ, 5% density

Pain stimulus with the fractional CO2 laser, 50 mJ, 5% density

Sponsors & Collaborators

• Netherlands Institute for Pigment Disorders

  lead OTHER

Principal Investigators

• Albert Wolkerstorfer, MD, PhD · Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Center, University of Amsterdam

• Menno A De Rie, MD, PhD · Department of Dermatology, Academic Medical Center, University of Amsterdam

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-10-01

Primary Completion

2016-12-01

Completion

2016-12-01