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High Intensity Focused Ultrasound for X-linked Dystonia-parkinsonism

NCT05592028 · Status: AVAILABLE · Type: EXPANDED_ACCESS

Last updated 2022-10-24

No results posted yet for this study

Summary

X-linked dystonia-parkinsonism (XDP) is a rare, X-linked, adult-onset, and progressive movement disorder seen almost exclusively in men from Panay Island in the Philippines. The disease is associated with mutations involving the DYT3/TAF1 gene, and all the cases described so far have been linked to Filipino ancestry. Although XDP is very rare globally, the prevalence is 5.74 per 100,000 individuals in Panay Island and 0.31 per 100,000 in the Philippines as a whole. Majority of patients (95%) were males, and the mean age of onset was 39 years. The mean duration of illness was 16 years, and the mean age of death was 55.6 years.

Conditions

  • X-Linked Dystonia Parkinsonism

Interventions

DEVICE

transcranial magnetic resonance-guided focused ultrasound pallidothalamic tractotomy

XDP patients will receive unilateral or bilateral transcranial magnetic resonance-guided focused ultrasound pallidothalamic tractotomy.

Sponsors & Collaborators

  • University of the Philippines Manila - Philippine General Hospital

    lead OTHER

Principal Investigators

  • Roland Dominic G Jamora, MD, PhD · Department of Neurosciences, University of the Philippines Manila

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Countries

  • Philippines

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05592028 on ClinicalTrials.gov