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Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application

NCT05506085 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 12

Last updated 2025-07-17

No results posted yet for this study

Summary

Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia (ADLD). Participants will undergo Deep Brain Stimulation surgery to treat laryngeal dystonia as part of their clinical care. Before surgery, as part of the study they will have specialized testing to study the movement of the vocal cords, as well as functional magnetic resonance imaging (fMRI). While in the operating room, researchers will examine brain waves to better understand how faulty brain firing patterns lead to dystonia. After surgery, and activation of the deep brain stimulator, participants will repeat speech testing and vocal cord imaging as well as magnetic resonance imaging (MRI).

Conditions

  • Laryngeal Dystonia
  • Adductor Spastic Dysphonia of Dystonia

Interventions

DEVICE

Deep Brain Stimulation

Deep Brain Stimulation of Globus Pallidus interna

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • Indiana University

    lead OTHER

Principal Investigators

  • Rita Patel, PhD · Indiana University

  • S. Elizabeth Zauber, MD · Indiana University

  • Kunal Gupta, MD, PhD · Indiana University

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-01
Primary Completion
2030-08-01
Completion
2030-08-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05506085 on ClinicalTrials.gov