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Long-term Stability of LFP Recorded From the STN and the Effects of DBS

NCT02915848 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2021-04-27

No results posted yet for this study

Summary

Movement disorders such as Parkinson Disease, dystonia, and tremor are related to abnormalities of part of the brain known as the basal ganglia. Recently, it has been suggested that the basal ganglia works by oscillations (group of neurons cycle between activation/deactivation when stimulated) of electrical signals. A treatment that involves insertion of electrodes in the subthalamic nucleus (STN) for electrical stimulation, known as deep brain stimulation (DBS), is an established treatment for advanced Parkinson's disease. However its mechanism of action is still not completely understood. Currently, DBS utilizes an "open loop" system whereby the stimulation settings are manually adjusted depending on the patients' clinical response.

1. Determine whether the local field potential (LFP) recorded from the STN is stable over a 1.5 year period.
2. Address whether STN LFP is a suitable control signal, and how it should be used to change DBS parameters

Conditions

Interventions

DEVICE

PC+S group

PC+S group: participants in the study will also receive a specific stimulation device (Activa PC+S, Medtronic) that is capable of recording the local field potentials (LFP). Approximately 10 participants are expected to take part in this study at UHN.

Sponsors & Collaborators

  • Medtronic

    collaborator INDUSTRY

  • University Health Network, Toronto

    lead OTHER

Principal Investigators

  • Robert Chen, FRCPC · University Health Network, Toronto

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-09-09
Primary Completion
2021-04-26
Completion
2021-04-26

Countries

  • Canada

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02915848 on ClinicalTrials.gov