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Effect of Oral NAD+ Precursors Administration on Blood NAD+ Concentration in Healthy Adults

NCT05517122 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 68

Last updated 2025-04-24

No results posted yet for this study

Summary

Nicotinamide adenine dinucleotide (NAD) is a coenzyme playing a central role in human metabolic pathways. A recognized approach to increase NAD level is through oral supplementation of its precursors promoting NAD synthesis in vivo. NAD precursors exist in multiple forms. However, it is unclear how the various precursors compare in their ability to increase NAD levels in human blood. The purpose of this study is to compare the effect of 3 NAD precursors on whole blood NAD metabolome.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

Nicotinamide (NAM)

500 mg a day

DIETARY_SUPPLEMENT

Nicotinamide Riboside (NR)

1000 mg a day

DIETARY_SUPPLEMENT

Nicotinamide Mono Nucleotide (NMN)

1000 mg a day

DIETARY_SUPPLEMENT

Microcrystalline cellulose

500 mg a day

Sponsors & Collaborators

  • Société des Produits Nestlé (SPN)

    lead INDUSTRY

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-12
Primary Completion
2022-11-24
Completion
2022-11-24

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05517122 on ClinicalTrials.gov