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The Effect of NAD Supplementation on Brain Vascular Health in Aging

NCT05483465 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 214

Last updated 2026-04-01

No results posted yet for this study

Summary

Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.

Conditions

  • Aging

Interventions

DRUG

Nicotinamide riboside

Oral NR, 1g/day per os for 8 weeks

DRUG

Placebo

Visually identical pill to NR, daily per os for 8 weeks

Sponsors & Collaborators

  • University of Pennsylvania

    collaborator OTHER

  • Oklahoma Medical Research Foundation

    collaborator OTHER

  • Elysium Health

    collaborator INDUSTRY

  • University of Oklahoma

    lead OTHER

Principal Investigators

  • Andriy Yabluchanskiy, MD, PhD · University of Oklahoma

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-05-03
Primary Completion
2027-06-30
Completion
2027-12-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Drugs
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05483465 on ClinicalTrials.gov