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Diabetes Reversal and the Subgingival Microbiota

NCT05501093 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 102

Last updated 2026-03-19

No results posted yet for this study

Summary

This study seeks to examine the impact of bariatric surgery on oral bacteria in diabetic compared to non-diabetic patients. The purpose of this research study is to examine how diabetes changes the bacteria in the mouth. This is an important question since bacterial changes may impact oral health. Participants will attend a screening and baseline visit prior to bariatric surgery and three post bariatric surgery appointments (3 weeks post, 6 months post and 1 year to 18 months post). Samples collected at each study visit include blood, plaque, and other oral samples. At the last study visit there is an optional dental cleaning.

Conditions

  • Diabetes type2
  • Bariatric Surgery Candidate

Interventions

OTHER

sample collection

Blood, plaque, and other oral samples

Sponsors & Collaborators

  • National Institute of Dental and Craniofacial Research (NIDCR)

    collaborator NIH

  • Temple University

    collaborator OTHER

  • Ohio State University

    collaborator OTHER

  • University of Pennsylvania

    lead OTHER

Principal Investigators

  • Dana Graves, DDS, DMSc · University of Pennsylvania

Eligibility

Min Age
25 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-03-11
Primary Completion
2025-06-30
Completion
2025-06-30

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05501093 on ClinicalTrials.gov