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Personalized Risk of Rapidly Progressive Atherosclerosis

NCT05492084 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 202

Last updated 2022-08-08

No results posted yet for this study

Summary

Вackground. Progressive atherosclerosis is accompanied by unfavorable clinical outcomes, study and understanding of this process, creation of risk assessment method is necessary for individualization of approaches to treatment and prevention of this condition.

Purpose of the study. Creation of a mathematical model to assess the risk of accelerated atherosclerosis development, using methods of factor and correlation analysis.

Patient Characteristics and Study Methods. A retrospective cohort study included 202 patients with coronary heart disease. Group 1 included patients who had had myocardial infarction or unstable angina, emergency arterial stenting, stroke, peripheral artery thrombosis, critical ischemia, and lower extremity amputation within 2 years before study inclusion. Patients in the comparison group did not have these events. The influence of each of the studied parameters on the probability of fast progressing atherosclerosis was determined by factor and correlation analysis. The prospective part of the study will include follow-up of patients from both groups for 12 months. Annual "endpoints": fatal outcome, unscheduled coronary revascularization, nonfatal myocardial infarction and stroke, hospitalization due to unstable angina pectoris, stent thrombosis, stenting/plasty of lower limb arteries.

Conditions

  • Atherosclerosis, Coronary

Interventions

OTHER

without Intervention

without Intervention

Sponsors & Collaborators

  • Novosibirsk State University

    collaborator OTHER

  • Novosibirsk State Medical University

    lead OTHER

Principal Investigators

  • Olga M. Parkhomenko · Novosibirsk State Medical University, Novosibirsk, Krasny pr 52, Russia

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-01
Primary Completion
2019-01-01
Completion
2019-01-31

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05492084 on ClinicalTrials.gov