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A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis

NCT05482256 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2025-10-24

No results posted yet for this study

Summary

The purpose of this research is to determine if detergents in everyday products such as toothpaste make the lining of the esophagus leaky and cause allergic inflammation.

Conditions

  • Eosinophilic Esophagitis

Interventions

DIAGNOSTIC_TEST

Esophageal String Test (EST)

Non-invasive, FDA-registered sampling method to evaluate eosinophilic inflammation in the esophagus. The EST is performed by having an individual swallow a capsule attached to a string which captures secretions from the esophagus. The end of the string is taped to the cheek and the capsule is swallowed with water. After 1 hour, the EST will be removed, and the string will be processed for laboratory analysis.

OTHER

Colgate

2 grams of toothpaste (pea sized amount) for 2 minutes

DIAGNOSTIC_TEST

High Resolution Esophageal Manometry (HREM)

Thin flexible tube with sensors placed in the nose and swallowed for esophagus placement to conduct reading regarding the lining of the esophagus taken for approximately 10 minutes

Sponsors & Collaborators

Principal Investigators

  • Benjamin Wright, MD · Mayo Clinic

Study Design

Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-12
Primary Completion
2023-02-10
Completion
2023-02-10

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05482256 on ClinicalTrials.gov