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Renal Considerations in the Heat Stress Recommendations (Aim2)

NCT05458843 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2023-11-08

No results posted yet for this study

Summary

An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is largely unknown, but may be related to kidney dysfunction caused by increases in body temperature and dehydration that elicit oxidative stress and inflammation in the renal tubules. The purpose of this study is to determine whether hydration status modifies the development of renal oxidative stress and inflammation.

Conditions

  • Hot Weather; Adverse Effect
  • Kidney Dysfunction
  • Kidney Injury
  • Hyperthermia
  • Dehydration

Interventions

PROCEDURE

Fluid replacement

Participants will drink Gatorade Zero ad libitum, up to 1 cup every 15 minutes.

PROCEDURE

No fluid replacement

Participants will not be permitted to drink.

Sponsors & Collaborators

  • State University of New York at Buffalo

    collaborator OTHER

  • Indiana University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
44 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-08-01
Primary Completion
2023-05-22
Completion
2023-05-22

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05458843 on ClinicalTrials.gov