Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry

Summary

The aim of the present study is to assess the metabolic impact of Continuous Renal Replacement Therapy and overview the obstacles and important factors compromising the use of Indirect Calorimetry in CRRT and suggest a model to overcome these issues.

Conditions

• Continuous Renal Replacement Therapy
• CO2 Removal
• Nutrition Poor
• Acute Renal Failure

Interventions

DIAGNOSTIC_TEST

blood gas analysis under citrate predilution

blood gas analysis of blood on different sample points and dialysis fluid

DEVICE

filter replacement

Using local protocol: stop and disconnect CRRT, replace filter and reconnect and restart CRRT.

DEVICE

IC

monitor patients during the whole study period with indirect calorimetry

DRUG

NaCl predilution

Replace citrate predilution with NaCl

DIAGNOSTIC_TEST

blood gas analysis under NaCl predilution

repeat blood gas analysis of blood on different sample points and dialysis fluid

DRUG

double ultrafiltration

double the ultrafiltration fluid by augmenting post dilution fluid and keeping ultrafiltration at the same rate.

DIAGNOSTIC_TEST

blood gas analysis under citrate predilution and double ultrafiltration rate

repeat blood gas analysis of blood on different sample points and dialysis fluid

DIETARY_SUPPLEMENT

pause and restart nutritional therapy

pause parenteral and enteral nutrition before indirect calorimetry is performed. and restart after first blood analysis for vitamine status

DIAGNOSTIC_TEST

evolution of vitamin and trace elements

blood analysis for vitamin and trace elements. Perform this blood analysis after restart of CRRT but before restart of nutritional therapy, 30 minutes after restart of nutritional therapy and 24h after restart of nutritional therapy.

Sponsors & Collaborators

• Universitair Ziekenhuis Brussel

  lead OTHER

Principal Investigators

• Elisabeth De Waele, Phd · Universitair Ziekenhuis Brussel

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-04-26

Primary Completion

2019-03-15

Completion

2019-03-15

Countries

• Belgium

Study Locations