Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)
NCT05453695 · Status: RECRUITING · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 36
Last updated 2026-03-03
Summary
Phase I dose-escalation safety and feasibility of IV DNase I in ICU septic patients.
Conditions
- Sepsis
- Critical Illness
Interventions
- DRUG
-
Intravenous DNase I
Dose-escalating intravenous infusion of DNase I
Sponsors & Collaborators
-
Canadian Institutes of Health Research (CIHR)
collaborator OTHER_GOV - lead OTHER
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 100 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-01-17
- Primary Completion
- 2026-05-28
- Completion
- 2026-09-30
Countries
- Canada
Study Locations
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