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Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock

NCT00159952 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2013-11-27

No results posted yet for this study

Summary

The purpose of this study is to determine the effect of the intensive insulin therapy on coagulation and fibrinolysis in patients affected by severe sepsis and septic shock. As a secondary endpoints the investigators will determine the effect of intensive insulin therapy on organ dysfunction and mortality of these patients.

Conditions

  • Severe Sepsis
  • Septic Shock

Interventions

PROCEDURE

intensive insulin therapy

control: glycemia will be controlled with insulin administration when higher than 215 mg/dL. treatment: glycemia will be controlled with be controlled with insulin administration when higher than 110 mg/dL

Sponsors & Collaborators

Principal Investigators

  • Luciano Gattinoni, MD · Policlinico Hospital of Milan

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-11-30
Primary Completion
2007-03-31
Completion
2007-11-30

Countries

  • Italy

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00159952 on ClinicalTrials.gov