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A Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis

NCT05448703 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2022-10-06

No results posted yet for this study

Summary

Radiation pneumonitis is the main dose-limiting toxicity of thoracic radiotherapy, which can affect life quality, survival, and the tumor-controlling effects of patients receiving thoracic radiotherapy.

The purpose of this study is to:

* Identify biomarkers including serum proteins, gene expression, genetic changes, and epigenetic modifications that determine radiation pneumonitis.
* Investigate the relationship between radiation pneumonitis and other toxicities induced by radiotherapy.
* Construct a predictive model for radiation pneumonitis.
* Evaluate survival and treatment outcome of patients with radiation pneumonitis.

Conditions

  • Radiation Pneumonitis

Interventions

OTHER

Blood Samples for Biomarkers

blood sample to be taken at baseline, during radiotherapy, and after radiotherapy

Sponsors & Collaborators

  • Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology

    collaborator UNKNOWN

  • Jingjiang People' Hospital

    collaborator UNKNOWN

  • Huazhong University of Science and Technology

    lead OTHER

Principal Investigators

  • Xianglin Yuan, PhD · Tongji Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-25
Primary Completion
2026-09-01
Completion
2026-09-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05448703 on ClinicalTrials.gov