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Effects of Sedation on Transpulmonary Pressure and Lung Homogenous

NCT03237806 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2018-03-20

No results posted yet for this study

Summary

The acute respiratory distress syndrome (ARDS) is characterized by severe respiratory failure. Open Lung and Lung Protective Strategy have been proved to improve mortality of ARDS patients. Preserving spontaneous breathing (SB) is good for inflating the lung lobe near diaphram during mechanical ventilation, however, strong respiratory drive could generate more transpulmonary pressure in ARDS patients, which increase the stress and strain in injured lung. Nonetheless, it's not clear if sedative has any effects on transpulmonary pressure of ARDS patients.The purpose of this study is to investigate the effects of sedation on transpulmonary pressure of ARDS patients.

Conditions

  • ARDS

Interventions

DRUG

Deep sedated

Midazolam intravenous continusly infusion, Deep sedated (Ramsay 5)

DRUG

Light sedated

Midazolam intravenous continusly infusion, Light sedated (Ramsay 3)

Sponsors & Collaborators

  • Southeast University, China

    lead OTHER

Principal Investigators

  • Songqiao Liu, Doctor · Department of Critical Care Medicine, Nanjing Zhong-da Hospital, School of Medicine, Southeast University

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-05-31
Primary Completion
2018-01-18
Completion
2018-03-18

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03237806 on ClinicalTrials.gov