Effect of Peripheral Vestibular Disease Location on Outcomes Following Home-based Virtual Reality Vestibular Therapy

Summary

This parallel-group randomized controlled trial aims to determine if the location of the lesion(s) in the vestibular system (unilateral versus bilateral, lateral semi-circular canal versus otolith) impacts the effectiveness of adjunct take-home head-mounted display (HMD) virtual reality (VR) therapy in improving patient symptomatology. Fifty patients meeting inclusion criteria will be recruited from the principal investigator's neurotology clinic. Baseline symptomatology questionnaires will be completed, followed by random allocation to virtual reality and control groups. Vestibular rehabilitation and virtual reality protocols will be adhered to for 4 to 8 weeks, followed by symptomatology questionnaires. Data analysis will be conducted to answer the study's objectives.

Conditions

• Peripheral Vestibular Disorder
• Benign Paroxysmal Positional Vertigo
• Meniere Disease
• Vestibular Neuritis
• Vestibular Neuronitis
• Labyrinthitis
• Herpes Zoster Oticus

Interventions

BEHAVIORAL

Standard Vestibular Rehabilitation with Adjunct At Home Virtual Reality Vestibular Rehabilitation

The virtual reality intervention will involve standard vestibular rehabilitation as described above and adjunct at home virtual reality video game. This video game will be projected on an android or apple device accommodated into a VR headset for 20 minutes daily until the vestibular rehabilitation is complete. This video will be congruent to current vestibular rehabilitation program exercises. Point-of-view games compatible with both Android and iOS devices will be evaluated by professionals to determine the game that is most representative of current evidence based exercises.

BEHAVIORAL

Standard Vestibular Rehabilitation with Adjunct Auditory Intervention

The control intervention will involve standard vestibular rehabilitation as described above and adjunct audio intervention while wearing the VR headset for 20 minutes daily until the vestibular rehabilitation is complete.

Sponsors & Collaborators

• University of British Columbia

  lead OTHER

Principal Investigators

• Desmond A Nunez, MD, MBA · Division of Otolaryngology, Department of Surgery, The University of British Columbia

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-06-01

Primary Completion

2025-09-30

Completion

2026-09-30

Countries

• Canada

Study Locations