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Smartphone-based Utility of the Vestibulo-ocular Reflex

NCT06856746 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 35

Last updated 2025-10-23

No results posted yet for this study

Summary

The goal of this observational study is to evaluate whether a novel smartphone-based (mHealth) application can accurately assess gaze stability and vestibulo-ocular reflex (VOR) function in adults with vestibular dysfunction. This pilot clinical ststudy includes adult participants with and without unilateral peripheral vestibular dysfunction to determine the feasibility of a mobile-based assessment of gaze stabilization.

The main questions it aims to answer are:

1. Can a prototype mHealth application accurately measure outcomes associated with standard dynamic gaze stabilization tests (e.g., static visual acuity, perception time, and maximal head velocity measurements)?
2. How well does a prototype mHealth application identify patients with unilateral peripheral vestibular dysfunction when compared to healthy volunteers?
3. Does a prototype mHealth application differ in identifying patients with unilateral peripheral vestibular dysfunction when compared to a commercially-available computer system that uses a gold-standard head-mounted sensor for gaze stabilization testing (GST)?

Participants will:

Perform the well-established GST protocol using a commercially-available computer system that uses a gold-standard head-mounted sensor Perform the well-established GST protocol a novel mHealth application

The following outcomes will be measured:

1. Standard visual acuity (SVA): The smallest readable target based on the user's best-aided vision
2. A perception time test (PTT): The shortest time a target can be accurately identified
3. A dynamic gaze stability test (GST): The maximal head velocity at which a patient can accurately identify the orientation of a presented visual target

This pilot clinical study will provide evidence to further support the use of mobile technology as a low-cost, accessible alternative for vestibular function assessment, particularly for patients in resource-limited settings.

Conditions

  • Vestibulo-Ocular Reflex (VOR) Dysfunction
  • Vestibular Function Tests
  • Vestibular Function Disorder
  • mHealth Application

Sponsors & Collaborators

  • National Institute on Deafness and Other Communication Disorders (NIDCD)

    collaborator NIH

  • University of Virginia

    lead OTHER

Principal Investigators

  • Adam Thompson-Harvey, MD · University of Virginia

  • Bradley Kesser, MD · University of Virginia

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-21
Primary Completion
2025-07-30
Completion
2025-07-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06856746 on ClinicalTrials.gov