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Dietary Sugar Absorptive Phenotype for Prediction of Weight Loss Outcome

NCT05408728 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 52

Last updated 2025-09-10

No results posted yet for this study

Summary

This study is trying to determine whether the success of bariatric surgery can be predicted by evaluating the dietary sugar absorptive characteristics in the small intestine and if there is any gene expression change on the dietary sugar absorptive characteristics.

Conditions

  • Obese
  • Healthy
  • Bariatric Surgery Candidate

Interventions

PROCEDURE

Endoscopic biopsy

Upper small intestinal biopsies from patients undergoing BS will be collected during routine standard of care screening EGD and again from the same patients at 1 year during routine standard of care surveillance EGD (esophageal reflux screening/surveillance). Biopsy-derived enteroid cultures and tissue samples from pre- and one-year post BS will be examined for expression level of sugar transporters and gluconeogenic enzymes; glucose and fructose absorption

Sponsors & Collaborators

Principal Investigators

  • Dilhana Badurdeen, MBBS, MD · Mayo Clinic

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-07-10
Primary Completion
2026-08-31
Completion
2026-08-31

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05408728 on ClinicalTrials.gov